• BCC is most common malignancy of skin, constitutes ~80% of all skin cancers (eMedicine)
  • Patients with xeroderma pigmentosum, who have a diminished capability for repairing sun induced mutations, develop a large number of basal cell and squamous cell carcinomas (SCCs) early in life
  • Multiple BCCs develop early in life in patients with basal cell nevus syndrome or Bazex syndrome
  • Trichoblastic carcinoma may be a more accurate term due to its predominant follicular differentiation and possible follicular origin
  • ~900,000 new individuals are diagnosed with BCC per year in US
  • Occurs in all races, but much more often in fair skinned people
  • Usually in patients > 40 years of age
  • More often in men than in women (male : female = 1.6:1)
  • Nipple: < 50 cases reported, usually age 60+ years, equal distribution between men and women

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